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in 1996. EXTOXNET no longer updates this information, but it may be useful
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E X T O X N E T
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EXTOXNET primary files maintained and archived at Oregon State
Revised June 1996
Trade and Other Names:
Trade names for commercial products containing vinclozolin
include BAS 352F, Drive, Ornalin, Ronilan, and Vorlan.
Vinclozolin may also be used in formulations with other
fungicides such as thiram, carbendazim, chlorothalonil, maneb,
Vinclozolin is a General Use Pesticide (GUP). It is toxicity
class III - slightly toxic. Products containing it carry the
Signal Word CAUTION on its label.
Vinclozolin is a dicarboximide nonsystemic fungicide that is used
for the control of several types of fungi in vines (such as
grapes), strawberries, vegetables, fruit, and ornamentals . It
may also be used on turf grass. This fungicide works by
inhibiting spore germination. It is available in dust, wettable
powder, smoke tablet, and water dispersible flowable granular
Formulation: It is
available in dust, wettable powder, smoke tablet, and water
dispersible flowable granular forms.
- Acute toxicity: Vinclozolin is
practically nontoxic in experimental animals. The acute
oral LD50 for vinclozolin is greater than 10,000 mg/kg in
rats and around 8000 mg/kg in guinea pigs . The
compound is a moderate skin irritant and will slightly
irritate the membranes in the nose and throat . The
reported dermal LD50 value is 72,000 mg/kg. The 4-hour
inhalation LC50 of a 50% concentration of vinclozolin is
greater than 29 mg/L of air in rats, indicating a rather
low toxicity by this route of exposure. Vinclozolin is a
moderate eye irritant [1,8].
- Chronic toxicity: Vinclozolin was fed to
dogs at relatively low levels (up to 50 mg/kg/day) for 6
months. Increases in the weight of the adrenal gland
occurred in the dogs at the middle doses (7.5 mg/kg/day)
for both sexes and males had enlarged prostates. Slightly
higher doses in females caused changes in the structure
of the adrenal gland. Another study with dogs fed small
amounts of vinclozolin showed chronic effects
(unspecified) at levels of 2.5 mg/kg and above . Dogs
are the most sensitive species of animal tested so far
. A 2-year feeding study with rats showed reductions
in body weight and changes in the blood chemistry at low
doses (about 25 mg/kg/day) . Male dogs experienced
changes in absolute weight and fat content of the kidney
at relatively low doses administered for 6 months. At
slightly higher doses (15 mg/kg) for the same length of
time (6 months), fat droplets appeared in the tubes
within the kidney . A single moderate dose (about 285
mg/kg) administered by injection to male mice resulted in
only minor changes in their kidneys .
- Reproductive effects: A study which
followed female rats through three successive litters
showed no effects on the reproduction of those litters at
doses of 72.9 mg/kg/day . These data suggest that
vincloazlin does not cause reproductive effects.
- Teratogenic effects: In one study on
mice, no birth defects were noted in the offspring of
pregnant females given large doses of vinclozolin (900
mg/kg/day) . However, the fungicide was toxic to the
fetuses. In a similar study on rats, no teratogenic
effects were observed at the same dose level . In
another study, rabbits were fed moderate amounts (up to
300 mg/kg/day) of the fungicide for an undisclosed amount
of time. No effects were noted in the animals at the
highest doses tested [8,13]. It appears that vinclozolin
is not teratogenic.
- Mutagenic effects: A number of tests on
the mutagenicity of vinclozolin have been negative. One
of the mutation tests was run at very high doses (2000
mg/kg/day) . Based on the information available, it
is unlikely that vinclozolin is mutagenic.
- Carcinogenic effects: A 2-year study on
rats showed no carcinogenic effects at the highest dose
tested (219 mg/kg) . Another study conducted over a
wide range of doses, produced some evidence of liver
tumors at 219 mg/kg/day over 2 years. These data suggest
that this compound is unlikely to have carcinogenic
effects in humans.
- Organ toxicity: Tests on dogs have shown
effects on the adrenal and prostate glands.
- Fate in humans and animals: Rats which
had been given a single dose of vinclozolin (level not
indicated) eliminated equal portions of the breakdown
products in urine and feces .
- Effects on birds: In the one bird
species tested, the bobwhite quail, the LD50 of
vinclozolin was 2510 mg/kg . This value indicates that
the compound is practically nontoxic to this species.
- Effects on aquatic organisms:
Vinclozolin is only moderately toxic to freshwater fish.
The LC50 (96-hour) for the compound is 130 mg/L in
guppies , and 52.2 mg/L in trout .
- Effects on other organisms: Vinclozolin
is nontoxic to honey bees and to earthworms .
- Breakdown in soil and groundwater:
Vinclozolin is of low to moderate persistence in soil. It
is only partially broken down by soil microorganisms .
Estimated half-lives of 3 days to greater than 3 weeks
have been reported . Field data indicate that
vinclozolin will be strongly sorbed to most soils with a
significant proportion of organic matter, and it is
unlikely to leach significantly [52,53].
- Breakdown in water: Photolysis and
hydrolysis may occur, and are pH dependent, with greater
photolysis and hydrolysis under neutral or slightly basic
- Breakdown in vegetation: In its
discussion of tolerance setting for vinclozolin in
grapes, the EPA stated that there is no reasonable
expectation for vinclozolin residues to be found in eggs,
milk, meat, or poultry from its use on table grapes .
- Appearance: Vinclozolin is a colorless
crystal with a slight aromatic odor .
- Chemical Name:
- CAS Number: 50471-44-8
- Molecular Weight: 286.11
- Water Solubility: 3.4 mg/L @ 20 C 
- Solubility in Other Solvents: v.s. in
ethanol, acetone, ethyl acetate, cyclohexane, benzene,
and xylene 
- Melting Point: 108 C 
- Vapor Pressure: 0.016 mPa @ 20 C 
- Log P: 3.00 
- Partition Coefficient: 100 (estimated)
- ADI: 0.07 mg/kg/day 
- MCL: Not Available
- RfD: 0.025 mg/kg/day 
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
Agricultural Products Division
P.O. Box 13528
Research Triangle Park, NC 27709-3528
- Phone: 800-669-2273
- Emergency: 800-832-4357
References for the information in this PIP can be found in
Reference List Number 10
information in this profile does not in any way replace or
supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide