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TRADE OR OTHER NAMES: Validamycin is also called Validamycin A. Trade names include Validacin, Valimon; and
Solacol (207, 243, 1).
REGULATORY STATUS: Validamycin is not registered for sale or use in the U.S. (243).
INTRODUCTION: Validamycin is a non-systemic antibiotic with fungicide action. It is produced from fermentation of
streptomyces hygroscopicus variety limoneus (207, 243). It is most effective against soil borne diseases and is used for the
control of Rhizoctonia solani in rice, potatoes, vegetables, and others as well as damping off diseases in vegetable seedlings,
cotton, sugar beets, rice and other plants (243, 1, 364).The U.S. EPA has classified validamycin as Toxicity Class IV-
practically non-toxic. For products containing validamycin, bearing a Signal Word is not required (1). Validamycin is found
as a soluble concentrate, a dustable powder, and a seed treatment (364).
- Acute Toxicity: Validamycin is practically non-toxic. The dose which kills half of the test animals, the LD50, is 20,000
mg/kg for rats and 2,000 mg/kg in mice (364). For skin exposure, the LD50 is greater than 5 gm/kg in rats. It is
non-irritating to skin when tested on rabbits (243).
- Chronic Toxicity: No information currently available
- Reproductive Effects: No information currently available.
- Teratogenic Effects: No information currently available.
- Mutagenic Effects: Spot tests and other studies of potential affects to DNA of Bacillus subtilis indicate that validamycin
is not mutagenic (365).
- Carcinogenic Effects: No information currently available.
- Organ Toxicity: No information currently available.
- Fate in Humans and Animals: No information currently available.
- Effects on Birds: No data are currently available.
- Effects on Aquatic Organisms: Validamycin is relatively non-toxic to fish. The LC50 (96hrs) for carp is 10 mg/l (1).
- Effects on Other Animals (Nontarget species): Validamycin is not toxic to bees (1).
- Breakdown of Chemical in Soil and Groundwater: Validamycin undergoes rapid microbial degradation in soil. The
half-life is less than 5 hours (1).
- Breakdown of Chemical in Water: No information currently available.
- Breakdown of Chemical in Vegetation: No information currently available.
PHYSICAL PROPERTIES AND GUIDELINES
- Appearance: Validamycin is a colorless, odorless hygroscopic powder. It is stable at room temperature in neutral or
alkaline media. It is slightly unstable in acidic media. Validamycin is non-corrosive.
- Chemical Name:
- CAS Number: 37248-47-8
- Molecular Weight: 497.5
- Water Solubility: Readily soluble in water.
- Solubility in Other Solvents: Soluble in methanol, dimethylformamide, and dimethyl sulfoxide. Slightly soluble in
ethanol and acetone
- Melting Point: 130-135 degrees C
- Vapor Pressure: Negligible at room temperature.
- Partition Coefficient: Not Available
- Adsorption Coefficient: Not Available
- ADI: Not Available
- MCL: Not Available
- RfD: Not Available
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
Takeda Chemical Industries Ltd.
12-10 Nihonbashi 2-ChomeChuo-ku
Tokyo 103 Japan
- Telephone: 81-3-3278-2567
References for the information in this PIP can be found in Reference List Number 10
DISCLAIMER: The information in this profile does not in any way replace or supersede the information on the pesticide
product label/ing or other regulatory requirements. Please refer to the pesticide product label/ing.