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in 1996. EXTOXNET no longer updates this information, but it may be useful
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EXTOXNET primary files maintained and archived at Oregon State
Revised June 1996
Trade and Other Names:
Trade names for products containing propetamphos include Blotic,
Safrotin, and Seraphos.
Propetamphos is a moderately toxic compound in EPA toxicity class
II. Labels for products containing propetamphos must carry the
Signal Word WARNING on the label. Most formulations of
propetamphos are General Use Pesticides (GUPs), but some may be
Restricted Use Pesticides (RUPs). RUPs may be purchased and
applied only by certified applicators.
Propetamphos is an organophosphate insecticide designed to
control cockroaches, flies, ants, ticks, moths, fleas, and
mosquitoes in households and where vector eradication is
necessary to protect public health. It is also used in veterinary
applications to combat parasites such as ticks, lice, and mites
in livestock. Commercial products include aerosols, emulsified
concentrates, liquids, and powders.
products include aerosols, emulsified concentrates, liquids, and
- Acute toxicity: Propetamphos is
moderately toxic via the oral route, with reported oral
LD50 values for propetamphos of 75 to 119 mg/kg in rats
[6,13]. Via the dermal route it is slightly to
practically nontoxic, with reported acute dermal LD50
values of 2300 to greater than 3100 mg/kg in rats and
greater than 10,000 mg/kg in rabbits [6,13]. The 4-hour
inhalation LC50 is greater than 2.04 mg/L in rabbits,
indicating slight toxicity via this route . Effects
due to acute exposure to propetamphos include those which
occur with exposure to other orghanophosphate pesticides,
including neurological and neuromuscular effects due to
cholinesterase inhibition . Symptoms of acute exposure
to organophosphate or cholinesterase-inhibiting compounds
may include the following: numbness, tingling sensations,
incoordination, headache, dizziness, tremor, nausea,
abdominal cramps, sweating, blurred vision, difficulty
breathing or respiratory depression, and slow heartbeat.
Very high doses may result in unconsciousness,
incontinence, and convulsions or fatality.
- Chronic toxicity: Rats fed propetamphos
for 13 weeks exhibited no effects at a low dose of 0.2
mg/kg/day. Over a 77-week study the rats exhibited no
adverse effects at or below the very low dose of 0.05
mg/kg/day. In a 2-year feeding studies with rats, there
were no effects noted at or below a dose of 6 mg/kg in
their diets. Dogs fed the compound for 6 months showed no
adverse effects at the dose of 0.05 mg/kg/day .
- Reproductive effects: A three-generation
rat study showed no significant effects in litters at 1
mg/kg/day . Available data suggest that propetamphos
does not cause reproductive toxicity.
- Teratogenic effects: A teratology study
in rabbits was negative . Available data indicate
that propetamphos is not teratogenic.
- Mutagenic effects: In studies with the
fruit fly Drosophila, propetamphos did not cause
chromosome damage . However, in mouse tissue, high
levels of the compound caused some mild chromosome damage
[93,94]. These data suggest that the compound is
nonmutagenic or weakly mutagenic.
- Carcinogenic effects: A two-year
carcinogenicity test on rats and a lifetime
carcinogenesis study on mice were both negative. The
highest dose administered to the rats was 6 mg/kg/day,
and the maximum dose administered to the mice was 21
mg/kg/day . This evidence suggests that propetamphos
does not cause cancer.
- Organ toxicity: The primary target organ
affected by propetamphos is the nervous system.
- Fate in humans and animals: Cultured
preparations of house fly, cockroach and mouse liver
cells all shown the ability to breakdown the compound
- Effects on birds: Propetamphos is
moderately toxic to birds. The acute oral LD50 for
propetamphos in the mallard ranges from 45 mg/kg to
nearly 200 mg/kg [13,8]. The dietary LC50 for the
compound in the mallard ranges from about 700 ppm to
greater than 1780 ppm . The LC50 for propetamphos in
the quail ranges from 138 ppm to 250 ppm .
Propetamphos is not generally used in outdoor settings,
and thus poses little risk to wildlife .
- Effects on aquatic organisms: The
compound is highly toxic to fish such as bluegill sunfish
and rainbow trout. The LC50 values range from 0.13 mg/L
in bluegill and 0.36 mg/L in rainbow trou,t to 3.7 to 8.8
mg/L in carp (moderately toxic range for carp) [13,8].
Propetamphos may be very highly toxic to aquatic
invertebrates, with reported LC50 values ranging between
0.68 ug/L and 14.5 ug/L in Daphnia magna .
- Effects on other organisms: No data are
- Breakdown in soil and groundwater: No
data are currently available.
- Breakdown in water: In water,
propetamphos is rapidly degraded only under extreme pH
conditions (acidic or basic), or in the presence of
- Breakdown in vegetation: No data are
- Appearance: Technical propetamphos is a
yellowish, oily liquid at room temperature .
- Chemical Name:
- CAS Number: 31218-83-4
- Molecular Weight: 281.30
- Water Solubility: 110 mg/L @ 24 C 
- Solubility in Other Solvents: v.s. in
acetone, chloroform, ethanol, and hexane 
- Melting Point: Not Available
- Vapor Pressure: 1.9 mPa @ 20 C 
- Partition Coefficient: Not Available
- Adsorption Coefficient: Not Available
- ADI: Not Available
- MCL: Not Available
- RfD: 0.02 mg/kg/day 
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
Sandoz Agro, Inc.
1300 E. Touhy Ave.
Des Plaines, IL 60018
- Phone: 708-699-1616
- Emergency: 708-699-1616
References for the information in this PIP can be found in
Reference List Number 5
information in this profile does not in any way replace or
supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide