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TRADE OR OTHER NAMES: Trade names for products containing monocrotophos include Azodrin, Bilobran,
Crisodrin, Monocil 40, Monocron, Nuvacron, Pillardrin, and Plantdrin (6, 13, 154).
REGULATORY STATUS: Use of monocrotophos on potatoes and tomatoes was withdrawn in 1985 (154). All
applications of monocrotophos were discontinued in the United States in 1988 (115). Before its withdrawal,
monocrotophos was a Restricted Use Pesticide (RUP) (127).
INTRODUCTION: Monocrotophos is an organophosphorus insecticide and acaricide which works systemically and on
contact. It is extremely toxic to birds and is used as a bird poison (6). It is also very poisonous to mammals. It is used to
control a variety of sucking, chewing and boring insects and spider mites on cotton, sugarcane, peanuts, ornamentals, and
tobacco (13,154). The EPA classifies monocrotophos as a class I toxicity - highly toxic. Products containing
monocrotophos bear the Signal Word "Danger" (112). Monocrotophos is available in other countries as a soluble
concentrate or an ultra-low volume spray (154).
- Acute Toxicity: Monocrotophos is a direct acting cholinesterase inhibitor capable of penetration through the skin (171).
The dose which kills half of the test animals, the LD50, is 17-18 mg/kg for male rats and 20 mg/kg for female rats. The
LD50 for dermal exposure is 126 mg/kg for male rats, 112 mg/kg for female rats, and 354 mg/kg for rabbits (154,126).
The concentration in air at which half of the test animals die, the LC50, is 0.8 mg/l air. Monocrotophos is not irritating to
skin and eyes (13). Symptoms of monocrotophos poisoning are similar to those of other organophosphate compounds.
Its cholinesterase inhibiting activity causes nervous system effects. Cases of human poisoning are characterized by
muscular weakness, blurred vision, profuse perspiration, confusion, vomiting, pain, and small pupils. There is a risk of
death due to respiratory failure (2, 163).
- Chronic Toxicity: No Information Available.
- Reproductive Effects: Rats who received doses of 2 mg/kg/day monocrotophos produced fetuses with lower than
average length and weight (170). This dose is much higher than expected from normal application of this pesticide.
- Teratogenic Effects: No teratogenic effects were found at 2 mg monocrotophos/kg/day in rats, the highest dose tested
- Mutagenic Effects: Studies show that monocrotophos may be weakly mutagenic (170).
- Carcinogenic Effects: Monocrotophos is not carcinogenic in rats at 0.45 mg/kg/day, the highest dose tested (170). No
significant carcinogenic lesions were observed when rats were exposed to monocrotophos aerosol at concentrations from
97-308 mg/m3 for one hour (171).
- Organ Toxicity: Monocrotophos affects the central nervous system by inhibiting cholinesterase, an enzyme essential for
normal nerve impulse transmission.
- Fate in Humans and Animals: Monocrotophos is metabolized and excreted rapidly and does not appear to accumulate
within the body (171). In mammals, 60-65% is excreted within 24 hours, predominantly in the urine (2).
- Effects on Birds: Monocrotophos is highly toxic to birds (154). The LD50 is 0.76 mg/kg for California quail, 0.94
mg/kg for bobwhite quail, 1.58 mg/kg for Canada goose, 3.3 mg/kg for European starling and 4.76 mg/kg for mallard
- Effects on Aquatic Organisms: Monocrotophos is moderately toxic to fish (154). The LC50 (48hrs) is 7 mg/l for
rainbow trout and 23 mg/l for bluegill sunfish (13). Monocrotophos causes reproductive damage to crustaceans exposed
for long periods of time (115).
- Effects on Other Animals (Nontarget species): Monocrotophos is highly toxic to bees (13). It may also kill non-target
birds which eat insects poisoned with monocrotophos (6).
- Breakdown of Chemical in Soil and Groundwater: Monocrotophos has a low environmental persistence. It doesnot
accumulate in soil because it is biodegradable. Its half-life is less than 7 days in soil exposed to natural sunlight
- Breakdown of Chemical in Surface Water: No information is currently available.
- Breakdown of Chemical in Vegetation: Monocrotophos has a half-life of 1.3 to 3.4 days on plant foliage (133). It
causes slight injury to some varieties of apple, pear, cherry, peach and sorghum (2).
PHYSICAL PROPERTIES AND GUIDELINES
- Appearance: Monocrotophos is a reddish brown crystalline solid with a mild odor (171).
- Chemical Name: dimethyl (E)-1-methyl-2-(methylcarbamoyl)vinyl phosphate
- CAS Number: 2157-98-4 (mixed isomers)
- Molecular Weight: 223.2
- Water Solubility: Soluble in water (154)
- Solubility in Other Solvents: soluble in acetone and alcohol (154)
- Melting Point: 54-55 degrees C (171)
- Vapor Pressure: 2.9 x 10-1 mPa (20 degrees C)
- Partition Coefficient: -0.22
- Adsorption Coefficient: Not Available
- ADI: 0.0006 mg/kg (13, 172)
- MCL: Not Available
- RfD: Not Available
- PEL: 0.25 mg/m3 (171)
- HA: Not Available
- TLV: 0.25 mg/m3 (171)
CIBA Agricultural Division
P.O. Box 18300
Greensboro, NC 27419-8300
References for the information in this PIP can be found in Reference List Number 5
DISCLAIMER: The information in this profile does not in any way replace or supersede the information on the pesticide
product label/ing or other regulatory requirements. Please refer to the pesticide product label/ing.