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EXTOXNET primary files maintained and archived at Oregon State
Revised June 1996
Trade and Other Names:
Trade names include Dithane, Dithane-Ultra, Fore, Green-Daisen M,
Karamate, Mancofol, Mancozeb, Mancozin, Manzate 200, Manzeb,
Manzin Nemispor, Nemispot, Policar, Riozeb, and Zimaneb.
Mancozeb is a practically nontoxic ethylene bisdithiocarbamate in
EPA toxicity class IV - practically nontoxic. It is registered as
a General Use Pesticide (GUP). Labels for products containing
mancozeb must bear the Signal Word CAUTION.
Mancozeb is used to protect many fruit, vegetable, nut and field
crops against a wide spectrum of fungal diseases, including
potato blight, leaf spot, scab (on apples and pears), and rust
(on roses). It is also used for seed treatment of cotton,
potatoes, corn, safflower, sorghum, peanuts, tomatoes, flax, and
cereal grains. Mancozeb is available as dusts, liquids, water
dispersible granules, as wettable powders, and as ready-to-use
formulations. It may be commonly found in combination with zineb
is available as dusts, liquids, water-dispersible granules,
wettable powders, and ready-to-use formulations. It is commonly
found in combination with zineb and maneb.
- Acute toxicity: Mancozeb is practially
nontoxic via the oral route with reported oral LD50 of
greater than 5000 mg/kg to greater than 11,200 mg/kg in
rats [1,3]. Via the dermal route it is practically
nontoxic as well, with reported dermal LD50 values of
greater than 10,000 mg/kg in rats, and greater than 5000
mg/kg in rabbits . It is a mild skin irritant and
sensitizer, and a mild to moderate eye irritant in
rabbits [4,32]. Workers with occupational exposure to
mancozeb have developed sensitization rashes .
- Chronic toxicity: No toxicological
effects were apparent in rats fed dietary doses of 5
mg/kg/day in a long-term study . Impaired thyroid
function was observed as lower iodine uptake after 24
months in dogs fed doses of 2.5 and 25 mg/kg/day of
mancozeb, but not in those dogs fed 0.625 mg/kg/day .
A major toxicological concern in situations of chronic
exposure is the generation of ethylenethiourea (ETU) in
the course of mancozeb metabolism, and as a contaminant
in mancozeb production [1,33]. ETU may also be produced
when EBDCs are used on stored produce, or during cooking
. In addition to having the potential to cause goiter,
a condition in which the thyroid gland is enlarged, this
metabolite has produced birth defects and cancer in
experimental animals .
- Reproductive effects: In a
three-generation rat study with mancozeb at a dietary
level of 50 mg/kg/day there was reduced fertility but no
indication of embryotoxic effects [1,9]. In another study
in which pregnant rats were exposed to mancozeb by
inhalation, toxic effects on the pups were observed only
at exposure levels (55 mg/m3) that were also toxic to the
dams . It is unlikely that mancozeb will produce
reproductive effects in humans under normal
- Teratogenic effects: No teratogenic
effects were observed in a three-generation rat study
with mancozeb at a dietary level of 50 mg/kg/day .
Developmental abnormalities of the body wall, central
nervous system, eye, ear, and musculoskeletal system were
observed in experimental rats which were given a very
high dose of 1320 mg/kg of mancozeb on the 11th day of
pregnancy . Mancozeb was not teratogenic to rats when
it was inhaled by pregnant females at airborne
concentrations of 0.017 mg/L . In pregnant rats fed 5
mg/kg/day, the lowest dose tested, developmental toxicity
was observed in the form of delayed hardening of the
bones of the skull in offspring . In view of the
conflicting evidence, the teratogenicity of mancozeb is
- Mutagenic effects: Mancozeb was found to
be mutagenic in one set of tests, while in another it did
not cause mutations . Mancozeb is thought to be
similar to maneb, which was not mutagenic in the Ames
Test . Data regarding the mutagenicity are
inconclusive but suggest that mancozeb is either not
mutagenic or weakly mutagenic.
- Carcinogenic effects: No data are
available regarding the carcinogenic effects of mancozeb.
While studies of other EBDCs indicate they are not
carcinogenic, ETU (a mancozeb metabolite), has caused
cancer in experimental animals at high doses [9,10].
Thus, the carcinogenic potential of mancozeb is not
- Organ toxicity: The main target organ of
mancozeb is the thyroid gland; the effects may be due to
the metabolite ETU [9,10].
- Fate in humans and animals: Mancozeb is
rapidly absorbed into the body from the gastrointestinal
tract, distributed to various target organs, and almost
completely excreted in 96 hours. ETU is the major
mancozeb metabolite of toxicologic significance, with
carbon disulfide as a minor metabolite .
- Effects on birds: Mancozeb is slightly
toxic to birds, with reported -day dietary LC50 values in
bobwhite quail and mallard ducklings of greater than
10,000 ppm . The 10-day dietary LC50 values of 6400
ppm and 3200 ppm are reported for mallard ducks and
Japanese quail, respectively .
- Effects on aquatic organisms: Mancozeb is moderately to
highly toxic to fish and aquatic organisms. Reported
48-hour LC50 are 9 mg/L in goldfish, 2.2 mg/L in rainbow
trout, 5.2 mg/L in catfish, and 4.0 mg/L in carp . The
reported 72-hour LC50 for mancozeb in crayfish is greater
than 40 mg/L; the 48-hour LC50 is 3.5 mg/L in tadpoles
- Effects on other organisms: Mancozeb is
not toxic to honeybees .
- Breakdown in soil and groundwater:
Mancozeb is of low soil persistence, with a reported
field half-life of 1 to 7 days . Mancozeb rapidly and
spontaneously degrades to ETU in the presence of water
and oxygen . ETU may persist for longer, on the order
of 5 to 10 weeks . Because mancozeb is practically
insoluble in water, it is unlikely to infiltrate
groundwater . Studies do indicate that ETU, a
metabolite of mancozeb, has the potential to be mobile in
soils . However, ETU has been detected (at 0.016 mg/L)
in only 1 out of 1295 drinking water wells tested .
- Breakdown in water: Mancozeb degrades in
water with a half-life of 1 to 2 days in slightly acidic
to slightly alkaline conditions .
- Breakdown in vegetation: When used as
directed, mancozeb is not poisonous to plants .
- Appearance: Mancozeb is a grayish-yellow
- Chemical Name: manganese
ethylenebis(dithiocarbamate) (polymeric) 
- CAS Number: 8018-01-7
- Molecular Weight: 266.31
- Water Solubility: 6 mg/L 
- Solubility in Other Solvents:
Practically insoluble in most organic solvents 
- Melting Point: Decomposes without
melting @ 192 C 
- Vapor Pressure: Negligible @ 20 C 
- Partition Coefficient: Not Available
- Adsorption Coefficient: >2000 
- ADI: 0.03 mg/kg/day 
- MCL: Not Available
- RfD: 0.003 mg/kg/day 
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
DuPont Agricultural Products
Walker's Mill, Barley Mill Plaza
Wilmington, DE 19880-0038
- Phone: 800-441-7515
- Emergency: 800-441-3637
References for the information in this PIP can be found in
Reference List Number 4
information in this profile does not in any way replace or
supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide