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in 1996. EXTOXNET no longer updates this information, but it may be useful
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E X T O X N E T
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EXTOXNET primary files maintained and archived at Oregon State
Revised June 1996
Trade and Other Names:
Trade names for commercial products containing iprodione include
Chipco 26019, DOP 500F, Kidan, LFA 2043, NRC 910, Rovral, and
Verisan. The compound is used in formulations with numerous other
fungicides such as thiabendazole and carbendazim. It is
compatible with most other pesticides.
Iprodione is a slightly toxic compound and products containing it
carry the Signal Word CAUTION on the label. Most products
containing iprodione are General Use Pesticides (GUPs). Chipco
26019 and Rovral (under some circumstances) may be Restricted Use
Pesticides (RUPs). RUPs may be purchased and used only by
Iprodione is a dicarboximide contact fungicide used to control a
wide variety of crop diseases. It is used on vegetables,
ornamentals, pome and stone fruit, root crops, cotton, and
sunflowers to control fungal pests, and may also be used as a
post harvest fungicide and as a seed treatment. Iprodione
inhibits the germination of spores and the growth of the fungal
- Acute toxicity: Iprodione is slightly
toxic by ingestion, with reported oral LD50 values of
3500 mg/kg in rats, 4000 mg/kg in mice, and greater than
4400 mg/kg in rabbits [1,8]. No dermal toxic effects were
noted at doses of over 2500 mg/kg in the rat and at 1000
mg/kg in the rabbit, indicating slight toxicity by this
route [1,8]. Inhalation toxicity is also low for this
compound. The 4-hour inhalation LC50 for iprodione is
greater than 3.3 mg/L in the rat .
- Chronic toxicity: Rats given dietary
doses of approximately 60 mg/kg/day over 1 1/2 years
suffered no ill effects [1,8]. Dogs fed approximately 60
mg/kg/day over 18 months also showed no adverse effects
[1,8]. In another study, beagle dogs fed dietary doses of
about 2.3 mg/kg/day for 1 year showed liver and kidney
weight increases. At doses starting at about 1.5
mg/kg/day, the dogs had decreased prostrate weights and
changes within red blood cells (damage to the hemoglobin
molecules). Females also had slight decreases in uterus
weights. No effects were noted below 0.5 mg/kg/day dose
- Reproductive effects: Female rats were
fed iprodione over three successive generations showed no
effects on reproduction at doses at and below 1.25
mg/kg/day . Reductions in fertility and fecundity
were not observed at doses of 5 mg/kg/day . Based on
these data, ioprodione is not likely to cause
- Teratogenic effects: There were no
developmental effects noted in the offspring of pregnant
rats receiving dietary doses of about 5.4 mg/kg/day .
However, the dose rate of about 120 mg/kg/day elicited
unspecified developmental toxicity in the rats .
Rabbits did not develop any dose-related toxicity at or
below 2.7 mg/kg/day of iprodione, but did develop
toxicity at 6 mg/kg/day . It appears that iprodione
is not likely to cause teratogenic effects at expected
- Mutagenic effects: No data are currently
- Carcinogenic effects: A 2-year feeding
experiment with rats showed no increases in tumor
formation or tumor precursors (neoplastic foci) at
dietary doses of about 2.5 mg/kg/day . An 18-month
study in mice showed cancer related effects at doses up
to approximately 22 mg/kg/day . Current evidence on
the carcinogenicity of iprodione is inconclusive.
- Organ toxicity: Target organs identified
in animal studies include the reproductive system
(prostate gland and uterus), liver, and kidneys.
- Fate in humans and animals: No data are
currently available .
- Effects on birds: Iprodione is slightly
toxic to wildfowl. The reported acute oral LD50 in
bobwhite quail is 930 mg/kg .
- Effects on aquatic organisms: Iprodione
is moderately toxic to fish species, with LC50 values
ranging from 2.25 mg/L in the sunfish to 6.7 mg/L in the
rainbow trout . Reported bioconcentration factors of
50 to 360 in carp and other fish species indicate low
bioconcentration potential .
- Effects on other organisms: Iprodione is
nontoxic to bees .
- Breakdown in soil and groundwater: The
half-life of iprodione in soil ranges from less than 7 to
greater than 60 days [1,11]. A representative half-life
in most soils is estimated to be 14 days .
Degradation rates vary with soil acidity, soil clay
content, and history of the soil fungicide treatment. In
soils that had been treated consistently with iprodione
for 10 or more years, slow or little breakdown of the
compound vinclozolin occurred, while in soil that had
been treated with vinclozolin rapid degradation of
vinclozolin and iprodione occurred . Iprodione is
slightly soluble and moderately to well sorbed by most
soils . These properties, combined with its short
field half-life indicate a low potential to contaminate
- Breakdown in water: The compound breaks
down very rapidly in water under aerobic conditions; the
rate is lesser, but still rapid under near-anaerobic
conditions . The compound is readily degraded by UV
- Breakdown in vegetation: The compound is
rapidly broken down in the plant after is taken up by the
roots and translocated . The main metabolite in plants
is 3,5-dichloroaniline . Iprodione alone or in
combinations with several other fungicides was not toxic
to plants (phytotoxic) .
- Appearance: Iprodione is a colorless,
odorless crystal .
- Chemical Name:
- CAS Number: 36734-19-7
- Molecular Weight: 330.17
- Water Solubility: 13 mg/L @ 20 C 
- Solubility in Other Solvents: v.s. in
ethanol, methanol, acetonitrile, toluene, benzene,
acetone, and dimethylformamide 
- Melting Point: 136 C 
- Vapor Pressure: <0.133 mPa @ 20 C 
- Partition Coefficient: 3.1004 @ 20 C 
- Adsorption Coefficient: 700 
- ADI: 0.2 mg/kg/day 
- MCL: Not Available
- RfD: 0.04 mg/kg/day 
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
Rhone-Poulenc Ag. Co.
P.O Box 12014
2 T.W. Alexander Dr.
Research Triangle Park, NC 27709
- Phone: 919-549-2000
- Emergency: 800-334-7577
References for the information in this PIP can be found in
Reference List Number 10
information in this profile does not in any way replace or
supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide