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The information in this profile may be out-of-date. It was last revised in 1996. EXTOXNET no longer updates this information, but it may be useful as a reference or resource.

Please visit the National Pesticide Information Center (NPIC) to find updated pesticide fact sheets. If you don't find a fact sheet related to your question, feel free to call 1-800-858-7378. NPIC is open five days a week from 8:00am to 12:00pm Pacific Time.

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E X T O X N E T

Extension Toxicology Network

Pesticide Information Profiles

A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program.

EXTOXNET primary files maintained and archived at Oregon State University

Revised June 1996

Iprodione

Trade and Other Names: Trade names for commercial products containing iprodione include Chipco 26019, DOP 500F, Kidan, LFA 2043, NRC 910, Rovral, and Verisan. The compound is used in formulations with numerous other fungicides such as thiabendazole and carbendazim. It is compatible with most other pesticides.

Regulatory Status: Iprodione is a slightly toxic compound and products containing it carry the Signal Word CAUTION on the label. Most products containing iprodione are General Use Pesticides (GUPs). Chipco 26019 and Rovral (under some circumstances) may be Restricted Use Pesticides (RUPs). RUPs may be purchased and used only by certified applicators.

Chemical Class: dicarboximide

Introduction: Iprodione is a dicarboximide contact fungicide used to control a wide variety of crop diseases. It is used on vegetables, ornamentals, pome and stone fruit, root crops, cotton, and sunflowers to control fungal pests, and may also be used as a post harvest fungicide and as a seed treatment. Iprodione inhibits the germination of spores and the growth of the fungal mat (mycelium).

Formulation: Not Available

Toxicological Effects:

• Acute toxicity: Iprodione is slightly toxic by ingestion, with reported oral LD50 values of 3500 mg/kg in rats, 4000 mg/kg in mice, and greater than 4400 mg/kg in rabbits [1,8]. No dermal toxic effects were noted at doses of over 2500 mg/kg in the rat and at 1000 mg/kg in the rabbit, indicating slight toxicity by this route [1,8]. Inhalation toxicity is also low for this compound. The 4-hour inhalation LC50 for iprodione is greater than 3.3 mg/L in the rat [8].
• Chronic toxicity: Rats given dietary doses of approximately 60 mg/kg/day over 1 1/2 years suffered no ill effects [1,8]. Dogs fed approximately 60 mg/kg/day over 18 months also showed no adverse effects [1,8]. In another study, beagle dogs fed dietary doses of about 2.3 mg/kg/day for 1 year showed liver and kidney weight increases. At doses starting at about 1.5 mg/kg/day, the dogs had decreased prostrate weights and changes within red blood cells (damage to the hemoglobin molecules). Females also had slight decreases in uterus weights. No effects were noted below 0.5 mg/kg/day dose [43].
• Reproductive effects: Female rats were fed iprodione over three successive generations showed no effects on reproduction at doses at and below 1.25 mg/kg/day [43]. Reductions in fertility and fecundity were not observed at doses of 5 mg/kg/day [43]. Based on these data, ioprodione is not likely to cause reproductive effects.
• Teratogenic effects: There were no developmental effects noted in the offspring of pregnant rats receiving dietary doses of about 5.4 mg/kg/day [43]. However, the dose rate of about 120 mg/kg/day elicited unspecified developmental toxicity in the rats [43]. Rabbits did not develop any dose-related toxicity at or below 2.7 mg/kg/day of iprodione, but did develop toxicity at 6 mg/kg/day [43]. It appears that iprodione is not likely to cause teratogenic effects at expected exposure levels.
• Mutagenic effects: No data are currently available.
• Carcinogenic effects: A 2-year feeding experiment with rats showed no increases in tumor formation or tumor precursors (neoplastic foci) at dietary doses of about 2.5 mg/kg/day [43]. An 18-month study in mice showed cancer related effects at doses up to approximately 22 mg/kg/day [43]. Current evidence on the carcinogenicity of iprodione is inconclusive.
• Organ toxicity: Target organs identified in animal studies include the reproductive system (prostate gland and uterus), liver, and kidneys.

• Fate in humans and animals: No data are currently available [43].

Ecological Effects:

• Effects on birds: Iprodione is slightly toxic to wildfowl. The reported acute oral LD50 in bobwhite quail is 930 mg/kg [1].
• Effects on aquatic organisms: Iprodione is moderately toxic to fish species, with LC50 values ranging from 2.25 mg/L in the sunfish to 6.7 mg/L in the rainbow trout [8]. Reported bioconcentration factors of 50 to 360 in carp and other fish species indicate low bioconcentration potential [8].
• Effects on other organisms: Iprodione is nontoxic to bees [1].

Environmental Fate:

• Breakdown in soil and groundwater: The half-life of iprodione in soil ranges from less than 7 to greater than 60 days [1,11]. A representative half-life in most soils is estimated to be 14 days [11]. Degradation rates vary with soil acidity, soil clay content, and history of the soil fungicide treatment. In soils that had been treated consistently with iprodione for 10 or more years, slow or little breakdown of the compound vinclozolin occurred, while in soil that had been treated with vinclozolin rapid degradation of vinclozolin and iprodione occurred [44]. Iprodione is slightly soluble and moderately to well sorbed by most soils [11]. These properties, combined with its short field half-life indicate a low potential to contaminate groundwater.
• Breakdown in water: The compound breaks down very rapidly in water under aerobic conditions; the rate is lesser, but still rapid under near-anaerobic conditions [8]. The compound is readily degraded by UV light.
• Breakdown in vegetation: The compound is rapidly broken down in the plant after is taken up by the roots and translocated [1]. The main metabolite in plants is 3,5-dichloroaniline [1]. Iprodione alone or in combinations with several other fungicides was not toxic to plants (phytotoxic) [45].

Physical Properties:

• Appearance: Iprodione is a colorless, odorless crystal [1].
• Chemical Name: 3-(3,5-dichlorophenyl)-N-(1-methylethyl)2,4-dioxo-1-imidazoline-carboxamide [1]
• CAS Number: 36734-19-7
• Molecular Weight: 330.17
• Water Solubility: 13 mg/L @ 20 C [1]
• Solubility in Other Solvents: v.s. in ethanol, methanol, acetonitrile, toluene, benzene, acetone, and dimethylformamide [1]
• Melting Point: 136 C [1]
• Vapor Pressure: <0.133 mPa @ 20 C [1]
• Partition Coefficient: 3.1004 @ 20 C [1]
• Adsorption Coefficient: 700 [1]

Exposure Guidelines:

• ADI: 0.2 mg/kg/day [12]
• MCL: Not Available
• RfD: 0.04 mg/kg/day [13]
• PEL: Not Available
• HA: Not Available
• TLV: Not Available

Basic Manufacturer:

Rhone-Poulenc Ag. Co.
P.O Box 12014
2 T.W. Alexander Dr.
Research Triangle Park, NC 27709

• Phone: 919-549-2000
• Emergency: 800-334-7577
  

References:

References for the information in this PIP can be found in Reference List Number 10

DISCLAIMER: The information in this profile does not in any way replace or supersede the information on the pesticide product labeling or other regulatory requirements. Please refer to the pesticide product labeling.