The information in this profile may be out-of-date. It was last revised
in 1996. EXTOXNET no longer updates this information, but it may be useful
as a reference or resource.
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updated pesticide fact sheets.
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E X T O X N E T
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University of Idaho, and the University of California at Davis
and the Institute for Environmental Toxicology, Michigan State
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USDA/Extension Service/National Agricultural Pesticide Impact
EXTOXNET primary files maintained and archived at Oregon State
Revised June 1996
Trade and Other Names:
Another common name is dodine acetate. Trade names include AC
5223, Apadodine, Carpene, Curitan, Cyprex, Efuzin, Melprex,
Sulgen, Syllit, Tebulan, Vandodine, and Venturol.
Dodine is a General Use Pesticide (GUP). It is registered for use
only in western states for peaches, pears, and cherries. It is
classified as toxicity class I - highly toxic. Products
containing it bear the Signal Word DANGER because of its
potential to cause severe eye irritation.
Dodine is a fungicide and bactericide used to control scab on
apples, pears, and pecans, brown rot on peaches, and several
foliar diseases of cherries, strawberries, peaches, sycamore
trees, and black walnuts. It is also used as an industrial
biocide and preservative. The compound works by changing the cell
walls of the fungus, causing loss of the materials from within
the cell. It is available as a soluble concentrate or a wettable
Formulation: It is
available as a soluble concentrate or a wettable powder.
- Acute toxicity: Because it may cause
severe eye irritation, dodine is considered a highly
toxic material . Dodine is slightly toxic via
inhalation or ingestion . The oral LD50 for technical
dodine in rats is 1000 mg/kg . The dermal LD50 in rats
is greater than 6000 mg/kg, and in rabbits is greater
than 1500 mg/kg for a single 24-hour contact, indicating
slight toxicity . Dodine did not cause allergic skin
reactions when tested on humans. However, it is an eye
and skin irritant .
- Chronic toxicity: Chronic dietary
exposure in rats caused reduced weight gain in both sexes
and reduced food consumption in males . Dogs fed
dodine for 12 months exhibited structural changes in the
thyroid, indicative of thyroid stimulation .
- Reproductive effects: In a 2-year
feeding study, rats given very high dietary doses of 800
mg/kg/day exhibited slight retardation of growth, but no
adverse effects on reproduction or lactation .
Offspring of mice fed dodine in the diet at doses of 74
to 89 mg/kg/day exhibited decreased numbers of pups
surviving to weaning . Dodine is unlikely to cause
reproductive effects in humans at expected exposure
- Teratogenic effects: No data are
- Mutagenic effects: Dodine does not
appear to be mutagenic. The Ames test for mutagenicity
was negative on five strains of bacteria .
- Carcinogenic effects: No data are
- Organ toxicity: Long-term animal studies
indicate that the thyroid was affected.
- Fate in humans and animals: No data are
- Effects on birds: The oral LD50 for
dodine in mallard ducks is 1142 mg/kg, suggesting that
the compound is only slightly toxic to birds .
- Effects on aquatic organisms: Dodine is
highly toxic to fish . The 48-hour LC50 for dodine in
harlequin fish is 0.53 mg/L .
- Effects on other organisms: Dodine is
nontoxic to bees . Its LD50 in honeybees is greater
than 11 mg/bee for topical application .
- Breakdown in soil and groundwater:
Dodine is of low persistence in soil. Its soil half-life
is about 20 days. It is soluble in water but binds
strongly to soil and so is unlikely to contaminate
- Breakdown in water: No data are
- Breakdown in vegetation: No data are
- Appearance: Dodine is a colorless or
white, slightly waxy crystalline solid .
- Chemical Name: 1-dodecylguanidinium
- CAS Number: 2439-10-3
- Molecular Weight: 287.44
- Water Solubility: 630 mg/L @ 25 C 
- Solubility in Other Solvents: s. in
methanol and ethanol; i.s. in most organic solvents 
- Melting Point: 136 C 
- Vapor Pressure: 1300 mPa @ 20 C 
- Partition Coefficient: Not Available
- Adsorption Coefficient: 100,000
- ADI: 0.01 mg/kg/day 
- MCL: Not Available
- RfD: 0.004 mg/kg/day 
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
Rhone-Poulenc Ag. Co.
P.O. Box 12014
2 T.W. Alexander Dr.
Research Triangle Park, NC 27709
- Phone: 919-549-2000
- Emergency: 800-334-7577
References for the information in this PIP can be found in
Reference List Number 10
information in this profile does not in any way replace or
supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide