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Pesticide Information Profiles
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TRADE OR OTHER NAMES: Product names include Talstar, Bifenthrine, Brigade, Capture, FMC 54800, OMS3024,
Torant (with Clofentezine), and Zipak (with Amitraz) (61, 11).
REGULATORY STATUS: Bifenthrin is a Restricted Use Pesticide (RUP). It is for retail sale to and use only by certified
applicators or persons under their direct supervision. It is only for the uses covered by the applicators certification (11). In
the U.S., bifenthrin is registered for use on greenhouse ornamentals and cotton (12).
INTRODUCTION: Bifenthrin is a member of the pyrethroid chemical class. It is an insecticide and acaricide which affects
the nervous system and causes paralysis in insects (61, 11). It is very highly toxic to fish and aquatic organisms (11, 62).
The U.S. EPA has classified bifenthrin as Toxicity Class II-moderately toxic. Products containing bifenthrin must bear the
SIGNAL WORD: WARNING. It is available as an emulsifiable concentrate or a wettable powder (12).
- Acute Toxicity: Bifenthrin is moderately toxic to mammals when ingested. Large doses may cause incoordination,
tremor, salivation, vomiting, diarrhea, and irritability to sound and touch (68). The dose at which half of the test animal
die, the LD50, for bifenthrin is about 54 mg/kg in female rats and 70 mg/kg in male rats (63). The LD50 for rabbits
whose skin is exposed to bifenthrin is greater than 2,000 mg/kg (11). Bifenthrin does not sensitize the skin of guinea pigs
(62). Although it does not cause inflammation or irritation on human skin, it can cause a tingling sensation which lasts
about 12 hours. It is virtually non-irritating to rabbit eyes (68).
- Chronic Toxicity: No information Available.
- Reproductive Effects: The dose at which no toxic effect of bifenthrin is observed on the mother (maternal toxicity
NOEL) is 1 mg/kg/day for rats and 2.67 mg/kg/day for rabbits. At higher doses, test animals had tremors (67). The dose
at which no toxic effect is observed on development (developmental toxicity NOEL) is 1 mg/kg/day for rats and is
greater than 8 mg/kg/day for rabbits (11).
- Teratogenic Effects: Bifenthrin does not demonstrate any teratogenic effects at the highest levels tested (100 ppm,
approximately 5.5 mg/kg/day) in a two-generational study in rats (63).
- Mutagenic Effects: Evidence of mutagenic effects from exposure to bifenthrin are inconclusive. Studies of mouse white
blood cells were positive for gene mutation. However, other tests of bifenthrinÕs mutagenic effects, including the Ames
test and studies in live rat bone marrow cells, were negative (11).
- Carcinogenic Effects: There was no evidence of cancer in a 2-year study of rats who ate as much as 10 mg/kg/day of
bifenthrin. However, an 87 week feeding study of mice with doses of 7, 29, 71, and 86 mg/kg showed a significantly
higher, dose related trend of increased tumor incidence in the male urinary bladder (63, 67). The incidence was
significantly increased at 86 mg/kg/day. Also, females had higher incidences of lung cancer than the controls at doses of
7 mg/kg and higher (67). The EPA has classified bifenthrin as a class C carcinogen, a possible human carcinogen (11,
- Organ Toxicity: Pyrethroids are poisons that affect the electrical impulses in nerves, over-stimulating nerve cells causing
tremors and eventually causing paralysis (11).
- Fate in Humans and Animals: Bifenthrin is absorbed through intact skin when applied topically (68). It undergoes
similar modes of breakdown within animal systems as other pyrethroid insecticides. In mammals, bifenthrin is rapidly
broken down and promptly excreted. Rats treated with 4 to 5 mg/kg, excreted 70 % in the urine and 20% in the feces
within 7 days. After 7 days, the remaining bifenthrin was found accumulated in tissues with high fat content such as the
skin and fat in males and females and the ovaries of females (67). Bifenthrin is less toxic to warm-blooded animals, such
as mammals, than to cold-blooded animals (68).
- Effects on Birds: Bifenthrin is moderately toxic to many species of birds (61). The dietary concentration (8 day) at
which half of the test animals die, the LC50, is 1,280 ppm for mallard ducks and 4,450 ppm for bobwhite quail (65). The
acute oral LD50 is 1,800 mg/kg for bobwhite quail and 2,150 mg/kg for mallard ducks. There is concern about possible
bioaccumulation in birds (63).
- Effects on Aquatic Organisms: Bifenthrin is very highly toxic to fish, crustaceans and aquatic animals (61, 11). The
LC50 after a 96-hour exposure is 0.00015 mg/l for rainbow trout, 0.00035 mg/l for bluegill, and 0.0016 mg/l for
Daphnia (12, 63). Because of its low water soilubility and high affinity for soil, bifenthrin is not likely to be found in
- Effects on Other Animals (Nontarget species): Bifenthrin is toxic to bees (62).
- Breakdown of Chemical in Soil & Groundwater: Bifenthrin does not move in soils with large amounts of organic
matter, clay and silt. It also has a low mobility in sandy soils that are low in organic matter. Bifenthrin is relatively
insoluble in water, so there are no concerns about groundwater contamination through leaching. ItÕs half-life in soil, the
amount of time it takes to degrade to half of its original concentration, is 7 days to 8 months depending on the soil type
and the amount of air in the soil (11, 62).
- Breakdown of Chemical in Vegetation: Bifenthrin is not absorbed by plant foliage, nor does it translocate in the plant
PHYSICAL PROPERTIES AND GUIDELINES: . It is photostable, stable to hydrolysis, has minimal volatility, and is
stable in storage. It has a negative temperature coefficient, so it works better at lower temperatures (66).
- Appearance: Bifenthrin is an off-white to pale tan waxy solid with a faint, slightly sweet smell (63)
- Chemical Name: (2-methyl-1,1-biphenyl-3-y1)-methyl-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl
- CAS Number: 82657-04-3
- Molecular Weight: 422.9
- Water Solubility: 0.1 mg/l (12)
- Solubility in Other Solvents: Bifenthrin is soluble in methylene chloride, acetone, chloroform, ether and toluene. It is
slightly soluble in heptane and methanol (12).
- Melting Point: 68-70.6 degrees C (63)
- Vapor Pressure: Not Available
- Partition Coefficient: >6
- Adsorption Coefficient: octonal/water) Kow = 1,000,000 (12)
- ADI: 0.015 mg/kg (12)
- MCL: Not Available
- RfD:0.015 mg/kg/day (64)
- PEL: Not Available
- HA: Not Available
- TLV: Not Available
- NOEL: 2.5 mg/kg/day (rat); 1.5 mg/kg/day (dog) (11, 64)
Agricultural Chemicals Group
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Philadelphia, PA 19103
- Telephone: 215-299-6000
- Emergency: 800-331-3148
REFERENCESReferences for the information in this PIP can be found in Reference List Number 2
DISCLAIMER: The information in this profile does not in any way replace or supersede the information on the pesticide
product label/ing or other regulatory requirements. Please refer to the pesticide product label/ing.