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E X T O X N E T
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EXTOXNET primary files maintained and archived at Oregon State
Revised June 1996
Trade and Other Names:
Ammonium sulfamate is also called AMS. Trade names include
Amcide, Amicide, Amidosulfate, Ammate, Ammate X-NI, Fyran 206k,
Ikurin, Silvicide, and Sulfamate.
Ammonium sulfamate was a General Use Pesticide (GUP) that was
discontinued by Du Pont in 1988. It was considered toxicity class
III - slightly toxic, and products containing ammonium sulfamate
had the Signal Word CAUTION.
Ammonium sulfamate (AMS) is an herbicide used to control many
types of woody plants, trees, herbaceous perennials, and annual
broadleaf weeds and grasses. AMS is a contact herbicide, which
means that it injures only those parts of the plant to which it
is applied. It is used primarily to control undesired growth
along rights-of-way and for general weed and poison ivy control
around homes, commercial buildings, and fruit orchards. AMS is
also used as a fertilizer.
Ammonium sulfamate is applied in water solution or oil-water
emulsion as a leaf, or foliar spray for control of woody plants,
or it is applied as crystals or concentrated solution to cuts in
the bark or on freshly cut stumps of trees to prevent
sulfamate is applied in water solution or oil-water emulsion as a
leaf, or foliar spray for control of woody plants, or it is
applied as crystals or concentrated solution to cuts in the bark
or on freshly cut stumps of trees to prevent re-sprouting.
- Acute toxicity: Ammonium sulfamate is
slightly toxic, with an oral LD50 of 3900 mg/kg in rats
and 3100 mg/kg in mice [1,58]. However, contact with
ammonium sulfamate may cause burns to the eyes . The
dust of ammonium sulfamate is irritating to the nose and
throat and can cause coughing or difficult breathing if
- Chronic toxicity: In a 105-day study
with rats fed 500 mg/kg/day, AMS did not cause signs of
poisoning. Some inhibition of growth was seen at doses of
1000 mg/kg/day . There was no skin irritation, nor
any signs of systemic toxicity, when 20% and 50%
water-based solutions were applied to the shaved skin of
- Reproductive effects: Reproduction was
not impaired when rats were given dietary doses of 17.5
or 25 mg/kg/day of AMS for 15 months . This suggests
that AMS does not cause reproductive effects.
- Teratogenic effects: No data are
- Mutagenic effects: Limited data indicate
that AMS in not mutagenic. The Ames/Salmonella assay was
negative for AMS, indicating that it does not cause
permanent changes in genetic material .
- Carcinogenic effects: A rat study
indicates that AMS is not carcinogenic at doses of 25
mg/kg/day . There are insufficient additional data to
confidently determine the carcinogenicity status of AMS
- Organ toxicity: Ammonium sulfamate may
cause gastrointestinal tract problems if it is eaten .
- Fate in humans and animals: AMS is
readily absorbed into the bloodstream from the
gastrointestinal tract . Following oral
administration of AMS to dogs for 5 days, 80 to 84% of
the dose was excreted as sulfamic acid in the urine.
- Effects on birds: AMS is practically
nontoxic to birds. The oral LD50 is 3000 mg/kg in quail
and 4200 mg/kg in ducks [22,1]. In a 14-day feeding
study, 150 and 590 mg/kg/day AMS had no effect on quail.
Quail fertility was not affected when 150 mg/kg/day was
mixed with their feed for two 10-day periods .
- Effects on aquatic organisms: Ammonium sulfamate is
practically nontoxic to fish. A 46% solution of AMS
becomes toxic in perch at 300 mg/L water . The LC50
(24-hour) of AMS is 1250 mg/L in harlequin fish . A
concentration of 30 mg/L of AMS had no effect on rainbow
trout and aquatic invertebrates .
- Effects on other organisms: Deer were
not harmed when they were fed AMS-treated leaves .
- Breakdown in soil and groundwater:
Ammonium sulfamate has a low to moderate persistence in
soil and can be decomposed by soil microbes in a 6- to
8-week period [1,28]. In regions with less moisture,
traces of AMS and its breakdown products may remain on or
in soil, water, or a crop for longer periods of time
. Soil may become temporarily nonproductive if AMS is
used at high rates . At dosages of 400 to 600 kg/ha it
can temporarily sterilize soil . AMS does not readily
bind, or adsorb, to soil particles. It dissolves readily
and may leach through the soil to groundwater .
- Breakdown in water: Ammonium sulfamate
absorbs moisture readily and is highly soluble in water
- Breakdown in vegetation: Ammonium
sulfamate is a contact herbicide, and causes injury only
to the parts of the plant to which it is applied. It is
absorbed rapidly through leaves, as well as through cut
surfaces on wood and is translocated to other parts of
the plant . It is nonselective and capable of killing
non-target plants .
- Appearance: Ammonium sulfamate is a
colorless, odorless, hygroscopic, water soluble
crystalline solid .
- Chemical Name: ammonium sulfamidate 
- CAS Number: 7773-06-0
- Molecular Weight: 114.13
- Water Solubility: 684,000 mg/L @ 25 C
- Solubility in Other Solvents: i.s. in
alcohol; s.s. in ethanol; s. in glycerols, glycols, and
- Melting Point: 131-132 C 
- Vapor Pressure: Negligible at room
- Partition Coefficient: Not Available
- Adsorption Coefficient: 30 (estimated)
- ADI: Not Available
- MCL: Not Available
- RfD: 0.2 mg/kg/day 
- PEL: 5 mg/m3 (8-hour) (dust) (respirable
- HA: 2 mg/L (lifetime) 
- TLV: Not Available
DuPont Agricultural Products
Walker's Mill, Barley Mill Plaza
P.O. Box 80038
Wilmington, DE 19880-0038
- Phone: 800-441-7515
- Emergency: 800-441-3637
References for the information in this PIP can be found in
Reference List Number 10
information in this profile does not in any way replace or
supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide